A new study revealed that vitamin D supplementation isn’t effective for reducing knee pain or slowing cartilage loss for people with knee osteoarthritis and low 25-hydroxyvitamin D levels.
Published in the March 8 issue of JAMA, the study did not find an evidence supporting vitamin D supplementation for slowing disease progression.
Symptomatic knee osteoarthritis occurs among 10% of men and 13%% of women age 60 years or older.
Presently, no disease-modifying therapies are available for osteoarthritis. Observational studies suggest that vitamin D supplementation is associated with benefits for knee osteoarthritis, but current evidence from clinical trials is contradictory.
In a study conducted in Tasmania and Melbourne, Australia, 413 patients with symptomatic knee osteoarthritis and low 25-hydroxyvitamin D were observed with oral vitamin D3 or an identical placebo for two years by Changhai Ding from the University of Tasmania.
The results show that vitamin D supplementation, compared to placebo, did not result in significant differences in change in MRI-measured tibial cartilage volume or a measure of knee pain over two-year period.
In addition, no significant differences was found in change of tibiofemoral cartilage defects or change in tibiofemoral bone marrow lesions.
“These data suggest a lack of evidence to support vitamin D supplementation for slowing disease progression or structural change in knee osteoarthritis,” according to the study’s authors.